Research was conducted at two locations over three years to determine the potential for Cotoran to carry over to flue-cured tobacco. Four two-year cotton/tobacco rotations were established, beginning in 1995 and 1996. Two were established at the Upper Coastal Plain Research Station near Rocky Mount, NC and two at the Lower Coastal Plain Research Station near Kinston. Cotton plots were 8 wide rows x 60 feet. The following year, tobacco plots were 6 rows transplanted in the center 40 feet of the previous year's plot. Treatments consisted of Cotoran applied preemergence either broadcast at 1.5 lb ai/a or as a 50% band at 1.5 lb ai/a (0.75 lb ai/planted acre) followed by none, one, or two POST-directed applications of Cotoran in a 50% band at 1.5 lb ai/a (0.75 lb ai/planted acre). Early POST-directed applications were made when cotton was 4-6 inches tall and late POST-directed applications were made to 8-12 inch cotton. After cotton harvest, fields were disked once. Prior to tobacco transplanting, fields were disked twice and bedded. All tillage operations were parallel to cotton rows.