New postemergence herbicides technologies and transgenic cotton varieties offer cotton producers potential for controlling difficult annual and perennial weeds. Current preplant and preemergence herbicides control Palmer amaranth (Amaranthus palmeri) and other broadleaf annuals, but spot-spray and hand-hoeing are generally needed for weed escapes. Field experiments were conducted in 1997 at several locations across the Texas High Plains to evaluate annual and perennial weed management in Roundup Ready, BXN, and Staple herbicide system management.