Cotton fruiting patterns were evaluated after non-labeled applications of Roundup Ultra (glyphosate) were applied over the top of Roundup Ready cotton at the 10 and 14 node stage of growth. The nodes surrounding the non-labeled application node had lower fruit retention than either the labeled application or the standard residual treatment. Cotton fruiting was generally shifted up the plant when non-labeled applications were applied. When non-labeled application are applied, yield becomes highly dependent upon the cotton plants ability to compensate for lost fruit. In unfavorable conditions, these non-labeled applications may lead to significant yield loss.