An experiment was conducted at three locations in 1996 and 1997 to evaluate the potential benefits of tank mixing MSMA with Staple for sicklepod (Senna obtusifolia) and other broadleaf weed control in cotton (Gossypium hirsutum). Treatments were a factorial arrangement of soil-applied herbicides by early postemergence (EPOST) herbicides and late post-directed (LPD) herbicides. Soil-applied herbicides included Prowl or Prowl plus Cotoran. EPOST treatments included no herbicide, Staple, MSMA, Staple plus MSMA, and a POST-directed application of Cotoran plus MSMA. LPD treatments included no herbicide or Bladex plus MSMA. All POST treatments were applied with a non-ionic surfactant at 0.25% (v/v). Cotton was not cultivated.