Selecting the most appropriate varieties can be a complex process that involves evaluation of numerous factors. First and foremost, both conventional and transgenic varieties must have good yield potential, be adapted to the production region and produce fiber of acceptable quality. Transgenic varieties with value added traits such as insect and herbicide resistance must be further evaluated in different production regions for their potential to offset higher seed costs and licensing fees. Conventional and transgenic varieties must also possess available genetic disease and nematode tolerance, boll types and other characteristics necessary for optimal production. Results from public and private variety evaluation trials conducted over years and locations provide good indicators of performance on which to base varietal selections. Since public testing of the transgenic varieties is still limited, growers must also rely on results from industry trials, comparisons of yield and quality characteristics with the parent varieties and their own experiences and observations.