This study analyzed the costs and returns to alternative harvest-aid treatments from a 5-year study in the Delta States of Arkansas, Louisiana, Mississippi, Missouri, and Tennessee. Results from this study indicate that harvest-aid treatments using Prep improved net revenues in northern growing areas but did not improve net revenues in southern growing areas. In southern growing areas, the increased costs from diminished harvest efficiency and delays in harvesting from un-defoliated cotton may improve the profitability of harvest-aids.