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Inflammatory and Immunotoxicological Activities of (1_3)- -Glucans

N. Ohno, N. N. Miura, Y. Adachi and T. Yadomae


(1->3)-b -Glucans exhibit a variety of biological activities, and the significance of these activities is dependent on the structure of the -glucans, such as solubility in water, molecular weight, degree of branching, and conformation. We have been analyzing the relationship between structure and activity of "gel-forming, high-molecular weight, soluble -glucans," such as schizophyllan (SPG), SSG, OL-2, and grifolan (GRN). We have a tentative conclusion that the soluble -glucans have almost no toxicity and that some of the activities, such as NO synthesis, vascular permeability, inflammatory cytokine synthesis, and limulus factor G activation, are significantly dependent on the conformation (single helix) of the -glucans. In addition, only GRN produced significantly high concentration of TNF- from macrophages in vitro. However, we exceptionally found that all the -glucans tested showed lethal toxicity in mice when administered with indomethacin. Large number of mice died within a week from the -glucan administration. Cytokine concentrations in sera of these mice were significantly increased by this treatment, suggesting that the lethal toxicity might be related to aberrance of the cytokine network.

Reprinted from Proceedings of the 1998 Beltwide Cotton Conferences pp. 240 - 244
©National Cotton Council, Memphis TN

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Document last modified Sunday, Dec 6 1998