The National Institute for Occupational Safety and Health (NIOSH), Centers for Agricultural Disease and Injury Research, Education, and Prevention were established as part of a Centers for Disease Control and Prevention (CDC) / NIOSH agricultural health and safety initiative begun in 1990. The Centers were established by cooperative agreement to conduct research, education, and prevention projects to address the nation's agricultural health and safety problems. Eight Agricultural Centers have been established in different geographic regions. Collectively, these Centers address many agricultural health and safety problems including respiratory disease. This presentation describes the NIOSH Agricultural Centers Program and ongoing efforts aimed at respiratory health problems in agriculture.