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Effect of Inhaled Cotton Dust Aqueous Extract on Cellular Structure of The Airway Epithelium of the Guinea Pig

A. Damanhouri, O.S. Tayeb and P.J. Nicholls


The effect of daily inhalation of aqueous extracts of cotton dusts were examined in the respiratory ciliated epithelium in guinea pig by electron microscopy. Following five days exposure, there was a significant loss of cilia, cellular disruption, detachment from basal membrane and swollen mitochondria compared to control. Extrusion of cellular components were also observed. This indicates that exposure of the guinea pig to cotton dust extract causes marked cellular damage to the airway epithelium. This toxic reaction may have an important role in the development of byssinosis.

Reprinted from Proceedings of the 1998 Beltwide Cotton Conferences pp. 185 - 188
©National Cotton Council, Memphis TN

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Document last modified Sunday, Dec 6 1998