Large plot variety tests were conducted at seven sites with histories of soil-borne diseases in the High Plains of Texas. In a site which was infested with Phymatotrichum omnivorum (cotton root rot), no varietal differences occurred for the incidence of dead plants, and the highest yielding varieties were Tamcot 'Sphinx' and All-Tex 'Atlas'. In a site with Fusarium wilt and Meloidogyne incognita (root-knot nematode), yield was correlated with an interaction between root-knot nematode density and incidence of wilt. The highest yielding variety was Paymaster 'HS26'. In a site with Fusarium wilt, root-knot nematode, and seedling disease (Rhizoctonia solani and Pythium), yield was correlated with all three factors, including an interaction between seedling disease and root-knot nematode. The highest yielding varieties were Stoneville 887 and Paymaster '330'. Verticillium wilt was not a serious problem in 1997, and in one of three fields selected for this disease, wilt was correlated with yield. All-Tex Atlas was either the first or second ranked variety in all three of these wilt sites. In a site where no disease occurred, no yield differences in the varieties were seen. Varietal tolerance or resistance to root-knot nematode, Fusarium and Verticillium wilts, and seedling diseases was observed.