Several defoliants were evaluated for their effect on defoliation, desiccation, open boll, and lint yield for S-7 Pima cotton during a three year period. The following combinations exhibited the greatest defoliation: Ginstar + Prep followed by Sodium Chlorate + Starfire; Ginstar followed by Ginstar; Dropp + Agridex followed by Ginstar; Prep + Dropp followed by Ginstar, or Sodium Chlorate + Harvade, or Sodium Chlorate + Folex, or Sodium Chlorate + Cotton Aide, or Starfire; and Cotton Quik + Ginstar. The following combinations exhibited the greatest desiccation: Ginstar followed by Ginstar; Prep + Dropp followed by Ginstar; Prep + Ginstar followed by Sodium Chlorate + Starfire; and Cotton Quik + Ginstar. There were minor differences among treatments in percent open boll. In all three years nearly all treatments had 90 percent or greater open boll. Lint yields were similar in most treatments. There were only minor differences in percent gin turnouts. However, there was a trend showing that treatments with poorer defoliation resulted in a slightly lower gin turnout.