In 1996, the interaction between DPL 33b and DPL 5415 cotton cultivars, early square loss, and mepiquat chloride application was investigated in a field study at St. Joseph, LA. There was a three-way interaction with respect to yield. DPL 33b appeared to have more vegetative vigor than it's recurrent parent, DPL 5415. Although early square loss resulted in a decrease in yield, a compensatory growth response was detected.