Plant growth regulators (PGRs) are widely used in cotton to control growth and enhance yield (Cothren, 1995). In recent years, PGR-lV has been successfully used to promote growth and enhance yields. PGRs are usually applied as foliar sprays during squaring and early flowering. However, little is known about applications made during mid- flowering. Field observations with late applications of 4 oz./acre of PGR-lV applied four weeks after flowering have shown enhanced boll opening and increased yield. Subsequent field plot research in Arkansas and Texas in 1994 to 1996 have shown that mid- to late-flowering applications of PGR-lV have the potential to enhance maturity and yield. However, the results have been inconsistent and further research is needed. Field plot research in Arkansas has indicated the potential of using PGR-lV during late-flowering to accelerate growth and boll retention to make up for excessive high shedding early. However, these preliminary results need to be further evaluated.