In-furrow applications of Furadan / Di-Syston were compared to Temik in in-house and university trials from 1993-1996 for efficacy against early season pests, and effects on cotton growth and development, yield and fiber quality. All measurements including efficacy evaluations on thrips and aphids, seedling growth response, plant structure and fruiting patterns, yield, and fiber quality were equivalent for these insecticide treatments. Comparisons of in-furrow applications of Furadan / Di-Syston and Gaucho seed treatment were conducted in university trials in 1995 and 1996. Furadan / Di-Syston resulted in greater efficacy against early season insects and also in greater yields than Gaucho seed treatment. Results of these studies demonstrate that Furadan / Di-Syston in-furrow applications are an effective at-planting insecticide treatnent providing equal or greater efficacy, promoting equivalent earliness, and resulting in equal or greater yield and quality in comparison to current alternatives. This combination also provides the added benefits of more accurate and uniform insecticide placement associated with liquid insecticide applications, as well as providing safening from herbicide injury for growers who utilize Command herbicide programs.