Results from previously published research, much of which is twenty to thirty years old, is quite varied in the effects that THIMET^® and TEMIK^® have on cotton plant stands and yields. Because of this lack of recent information and reports of phytotoxic responses, a three year study to evaluate the interaction effects of either THIMET or TEMIK and seed vigor was conducted. The systemic insecticides were placed in-furrow at a slightly exaggerated rate of 1.00 pound (AI) per acre on excellent seed (vigor index > 160) and on poor seed (vigor index < 120). Cotton treated with THIMET and TEMIK significantly increased yields an average of 91 pounds lint per acre over the untreated for the three years of testing. For the same time period, no differences were seen between THIMET or TEMIK in their effect on stand or yield. Seed vigor indexes were shown to have a high degree of correlation with final stands with the higher indexes producing the highest stands. The presence of systemic insecticides tended to increase final stands over the untreated check. Stands and yields were greatly influenced by the environmental conditions encountered.