Field tests were conducted at the St. Joseph and Macon Ridge locations of the Northeast Research Station in 1996 to evaluate conventional cotton varieties and experimental BXN/Bt and or Bt genotypes with Bollgard^®. Three conventional varieties (ST 474, ST 495, and ST 125) were include as standards, and compared to seven genotypes which contained genes to metabolize bromoxynil (BXN^® system) and/or the Bollgard gene. The varieties and experimental genotypes were tested with (W) and without (WO) applications of insecticides for major pest control. Effectiveness of major pest insect control strategies was determined by counting square damage resulting from bollworm (BW), tobacco budworm (TBW), boll weevil and beet armyworm (BAW) and estimating yields. Analyzed across all treatments, major pest control resulted in significantly less square damage at both the St. Joseph and Winnsboro locations. The genotypes with Bollgard resulted in significantly less square damage as compared to the conventional varieties, except that Bt02, BXN/Bt03, and BXN/Bt06 were not significantly better than ST 474 at the St. Joseph location and BXN/Bt06 was not significantly better than ST 495 at Winnsboro. Major pest control strategies resulted in significantly improved lint yield/acre across all treatments as compared to the untreated control at both locations. At the St. Joseph location, Bt07 produced significantly higher lint yield/acre as compared to all other genotypes. Three experimental lines, BXN/Bt01, BXN/Bt03 and Bt07, produced >1000 lb lint/acre at both locations. Lint yield/acre of conventional varieties was highest for ST 474, followed by ST 495, and ST 132 (tested only at the St. Joseph location).