Although dramatic changes have occurred in weed control in many crops, few selective POST cotton herbicides have been available to producers for controlling weeds without causing injury or delaying cotton maturity. The potential of utilizing Staple, Roundup Ultra, and Buctril in a cotton weed control program include: 1) effective control of many weed species, 2) reduced herbicide usage since POST programs allow treating weeds on an as-needed basis rather than a preventative basis, 3) less reliance on PPI herbicides would facilitate minimum-tillage production practices, 4) allowing a wider herbicide application timing to control weeds, and 5) offering herbicides for in-season weed control with different mechanisms of action, which could reduce or delay development of resistance to herbicides currently used.