The amount of cotton produced using conservation tillage production techniques is increasing rapidly in south Texas and northeastern Mexico. Conservation tillage is being adopted due to benefits from decreases in wind and water erosion, sandblasting of seedling cotton, time, equipment, labor, fuel, and increased net returns when compared to a conventional moldboard plow tillage system. Objectives of this study were to identify weed management techniques which are effective for cotton production in no-tillage maize or grain sorghum residue. Sixteen weed management treatments were evaluated for crop injury, control of Amaranthus Palmeri and Panicum Texanum and effects on no-tillage cotton lint yields. Single herbicide treatments did not provide acceptable control of Amaranthus Palmeri and Panicum Texanum Tank mix combinations of several herbicides provided superior season long weed control and cotton lint yields in subtropical no-till cropping conditions. These herbicide combinations included pendimethalin plus fluometuron, clomazone plus pyrithiobac, pendimethalin plus pyrithiobac, fluometuron plus pyrithiobac, and pendimethalin plus fluometuron plus pyrithiobac.