Research was conducted at three locations in North Carolina to evaluate Staple, MSMA (Bueno 6), and Staple plus MSMA tank mixtures for weed control and cotton yields in conventional- and no-till production systems. For conventional systems Treflan was applied PPI at 0.75 lb ai/ac to all plots while Dual at 1.0 lb ai/ac was applied PRE to all plots in no-till systems for annual grass weed control. Management systems included a factorial arrangement of PRE, early postemergence, and LAYBY options for a total of 26 management systems. PRE options were 1) none or 2) Cotoran at 1.5 lb ai/ac. Early postemergence options were 1) nothing, 2) Cotoran at 1.0 lb ai/ac plus MSMA at 2.0 lb ai/ac applied early post-directed, and the remaining options were applied postemergence over-the-top and included 3) Staple at 0.064 lb ai/ac, 4) Staple at 0.032 lb ai/ac, 5) Staple at 0.064 lb/ac plus MSMA at 1.0 lb/ac, 6) Staple at 0.032 lb/ac plus MSMA at 1.0 lb/ac, and 7) MSMA at 1.0 lb ai/ac. Staple was applied with a nonionic surfactant at 0.25% of the spray volume. All herbicides were applied at 15 GPA at 19 to 30 PSI.