Gel Permeation Chromatography was used to compare peak, weight-average, and number average molecular weights of cotton fabric before and after treatment with a total cellulase preparation. Fabric was treated in either a Launderometer or a reciprocal water bath/shaker for times ranging from 10 to 180 minutes. Weight loss and breaking load measurements on control fabrics, buffer-only treated fabrics, and cellulase-treated fabrics were compared to molecular weight data. Despite considerable weight loss and breaking load reduction produced by treatment in the Launderometer with a total cellulase, GPC analysis did not show a reduction in molecular weight of the cellulose .