Folocron research across the Cotton Belt has given a consistent 10% lint yield increase from mid-season foliar applications. In Arkansas, California and Texas, yield responses have been associated with increases in boll numbers and boll weight. Other innovative research with Folocron on stressed cotton seedlings has shown enhanced growth after relief of the stress(Morse, et al 1996). Folocron has continued to demonstrate a higher return on investment over both foliar urea and the untreated control. Foliar fertilization with nitrogen (N) is continuing to advance as a standard management practice in the Cotton Belt even in the mist of recent reports of poor response to the applied fertilizer later than three weeks after first flowering. Controlled Release Nitrogen (CRN) fertilizers, such as Folocron may be the solution to these problems.