Pix (mepiquat chloride) has been evaluated on cotton by researchers since the late 1970's. It has been applied to accomplish numerous different benefits, under many varied conditions, and has had positive benefits when applied to most cotton crops in the San Joaquin Valley. Greatest increases with Pix are to late planted cotton, rank growing cotton, cotton which has lost early fruit set, and narrow row cotton. It is used at various rates and timings according to needs, and is applied in low rate multiple doses, and in tank mixes with other chemicals. Generally, the use of Pix results in increased lint yields due to increased boll set and retention. Crop earliness has also been documented in many cases.