Developments in crop plant biotechnology can shift crop production functions, changing the profitability and optimal enterprise selection in a farm plan. Cotton production on the High Plains of Texas will be affected by crop biotechnology. Representative farm modeling was used to estimate the effects on profitability and enterprise selection due to expected biotechnological advances in major crops at the farm level. Biotechnology is estimated to significantly contribute to the profitability of farms in the High Plains of Texas. Likewise, such developments can be expected to result in increased cotton acreage in the region.