With emphasis on conservation-tillage crop production increasing it is necessary to develop an effective weed management program in cotton. Banded and broadcast preemergence (PRE) applications of Prowl + Cotoran followed by Staple (Early-POST) were evaluated in combination with Roundup/shielded sprayer applications and conservation-tillage cultivations made 3, 5, and 7 weeks after planting. Generally, broadcast herbicide applications were necessary for adequate weed control and maximum lint yields. No differences in weed biomass and lint yields were evident between Roundup/shielded sprayer applications and conservation-tillage cultivations. Two Roundup/shielded sprayer applications or cultivations provided greater weed control, and lower weed biomass compared the a single application. However, weed control, weed biomass, and lint yields were similar with two or three Roundup/shielded sprayer applications or cultivations.