No-till and stalebed cotton production both require the use of herbicides to control vegetation prior to planting. The two primary preplant herbicides are Gramoxone or Roundup. There are over twenty broadleaf weeds commonly found in Arkansas reduced tillage fields. Of these weeds, horseweed (HW) and cutleaf eveningprimrose (CLEP), are the most troublesome. These two weeds can overwinter as a rosette and persist throughout the cotton growing season. Unfortunately, Roundup is effective on HW but not CLEP. Gramoxone is somewhat effective on CLEP but provides poor control of HW. The purpose of our research was to evaluate several herbicide combinations for HW and CLEP control, and to determine cotton tolerance to these herbicides.