Field studies were conducted at four locations in North Carolina and Georgia to evaluate Buctril and Staple systems for weed control, crop injury, and yield in reduced and no-till BXN cotton. Herbicide systems were a factorial arrangement of PRE, EPOST, POST, and LAYBY options. PRE treatment options consisted of a) Gramoxone Extra at 0.25 lb ai/ac, and Staple at 0.094 lb ai/ac. EPOST treatment options consisted of a) Buctril at 0.375 lb ai/ac, and Buctril + MSMA at 1.0 lb ai/ac. POST treatment options consisted of a) none, and b) Buctril. LAYBY treatment options consisted of a) none, and b) Bladex at 0.80 lb ai/ac + MSMA. Additional treatments consisted of Gramoxone Extra PRE or Gramoxone Extra + Staple PRE alone or fb Cotoran 1.0 lb ai/ac + MSMA post-directed (PDS) or fb Cotoran + MSMA PDS or fb Bladex + MSMA LAYBY. A non-treated check was also included. PRE treatments received a NIS at 0.25% (v/v). All treatments were applied using a CO₂ backpack sprayer delivering 17-20 GPA at 20-30 PSI. Weeds evaluated included redroot pigweed (Amaranthus retroflexus L.), sicklepod [Senna obtusifolia (L.) Irwin and Barneby], Ipomoea morningglory species (Ipomoea spp. L.), common cocklebur (Xanthium strumarium L.), common lambsquarters (Chenopodium album L.), and common ragweed (Ambrosia artemisiifolia L.). Studies were conducted at Calhoun and Tifton, GA in 1994 and at Richfield and Clayton, NC in 1995. Data represent averages over four locations.