Field studies were conducted in 1995 at the Upper Coastal Plain Research Station in Rocky Mount, North Carolina to evaluate preplant incorporated (PPI), preplant (PRE) and postemergence (POST) herbicide treatments applied alone or in a system with other herbicides for weed control, lint yield and stand reduction in cotton. ‘BXN 57' cotton was planted with Di-Syston at 0.75 lb ai/a in-furrow on beds spaced 36" apart. Herbicide systems evaluated consisted of a factorial arrangement of two PPI, four PRE, and two POST options. The PPI treatments were Zorial at 0.6 lb ai/a and Treflan at 1.2 lb ai/a. Zorial at 0.6 lb SPLIT (.3lb PPI fb .3 lb PRE), Cotoran at 1.2 lb, Command at 0.75 lb, and Staple at 1.0 oz ai/a were the PRE options. The two POST options were Staple at 1.0 oz + 0.25% v/v NIS and Buctril at 0.5 lb ai/a. All treatments were applied with a CO₂ backpack sprayer equipped with 11002VS tips calibrated to deliver 16.7 GPA at 29 PSI. Weeds evaluated were: common lambsquarters (Chenopodium album L.), Pennsylvania smartweed (Polygonum pensylvanicum L.), morningglory species (Ipomoea ssp L.), large crabgrass [Digitaria sanguinalis (L.) Scopoli], prickly sida (Sida spinosa L.) and redroot pigweed (Amaranthus retroflexus L.). The experimental design was a randomized complete block with three replications.