Weed control in Roundup Ready^TM cotton was evaluated in three experiments at two locations in South Carolina in 1995. Roundup applied postemergence (POST) provided excellent early-season control of Palmer amaranth up to 9 inches in height. POST control of sicklepod and common cocklebur with Roundup ranged from 88 to 100 and 90 to 100% 2 to 6 weeks after treatment (WAT), respectively. Roundup provided 71 to 93% control of entireleaf morningglory and ivyleaf morningglory. At one location two applications of Roundup were need to achieve satisfactory control. In most experiments a soil-applied herbicide improved late-season broadleaf weed control.