Foliar fertilization with nitrogen (N) is a widely used practice but there have been reports of poor response to the applied fertilizer later than three weeks after first flowering. The introduction of slow release nitrogen (SRN) fertilizers, such as FOLOCRON may solve these problems. Results of research conducted in Arkansas, California and Texas have shown yield increases averaging 10% from mid-season foliar applications of FOLOCRON. These increases were associated with increased boll numbers and boll weight. Other innovative research with FOLOCRON on drought-stressed cotton seedlings have shown enhanced growth after relief of the stress. The profit analyses from these applications is presented showing a net return of $35.72/A compared to the control and $12.73 compared to urea foliar applications.