Variations in the performance of paraquat have been observed when it has been applied at different times of the day. A study was conducted to determine the optimal time of day to apply Cyclone® for cotton desiccation and the best rate of Cyclone® to be applied at this time. Treatments included an untreated check and Cyclone® applications of 4, 8, and 16 oz/A, each applied at three times (8 A.M., 1 P.M., and 6 P.M.). The best rate was the 16oz/A rate. The best time of application was the 6 P.M. timing. The results obtained from this study indicate that for best results, Cyclone® applications should be made in the evening with a rate of 16 oz/A.