The Mississippi Agricultural and Forestry Experiment Station project to evaluate cost reduction strategies and major production changes instituted by industry, growers or researchers, and to revitalize a cooperative effort to develop decision making tools and simulators, was initiated in the spring of 1995. Field size units with a minimum of 25 acres per treatment were established in Lee, Madison, Tallahatchie and Yazoo Counties with each site serving as a replicate for the experimental treatments. All treatments were also replicated 4 times in field size units in Leflore Co. Small plot strategy research was also initiated in a delta and a hill location to help develop techniques to be advanced to the large plot trials and hence to growers. Fields of NuCotn33 (transgenic, B.t. cotton) that received no heliothine control, was compared in each location with DPL 5415 and a grower-chosen variety that received season long control of Lepidoptera according to the Mississippi Insect Control Guide. Average lint yield and insecticide input cost (insecticide only) results for all sites for the NuCotn33, DPL 5415, and 'grower variety' treatments, respectively, are: 840 lb., $35.37; 668 lb. $96.65; and 717 lb. $93.78. A fourth treatment that was to evaluate aggressive early season plant bug control was not triggered because of very low early season populations of tarnished plant bug.