Forty-five large scale PIRATE Insecticide-Miticide Experimental Use Permit (EUP) trials were conducted in AR, LA, MS, and TN cotton fields comparing PIRATE with commercial insecticides for control of the tobacco budworm, Heliothis virescens (F.), and cotton bollworm, Helicoverpa zea (Boddie), complex (TBW/CB). Insecticide treatments were broadcast applied by ground and air and were tested alone and tank-mixed with companion insecticides. Results from the PIRATE Program support the strong fit for PIRATE as a new tool for controlling TBW/CB in cotton including organophosphate, carbamate, and pyrethroid resistant TBW. In the comparisons of PIRATE with chemical insecticides for TBW/CB control, PIRATE was equal to or superior to the comparison treatment in 127 of 146 comparisons (87%). PIRATE stand alone at 0.3-0.35 lb (AI)/acre provided good control of TBW/CB. When tank-mixed with a companion insecticide, PIRATE at 0.2-0.25 lb (AI)/acre effectively controlled TBW/CB. Control at these stand alone and tank mix rates of PIRATE was equivalent or superior to competitive insecticides and mixtures.