Information is very limited on the interaction of reniform nematodes and silverleaf whiteflies and their effects on cotton, especially in regards to the quality and vigor of seed produced under these stresses. In 1995, studies were conducted to ascertain the single and combined effects of reniform nematodes and silverleaf whiteflies on cottonseed quality and vigor. In a split-plot design, nematode treatments (Telone II and control) were the whole plots and whitefly treatments (imidacloprid and control) were the subplots. Across the nematode treatments, seed index of the Telone II plots was 9.1 compared to 8.7 for the control. Within the Telone II treatment, seed index was reduced from 9.7 to 8.4 by the silverleaf whiteflies, while within the reniform-infested treatment, whitefly stress reduced seed index from 9.0 to 8.3. Cool germination (65oF) ragdoll tests indicated that seed produced under whitefly infestations had lower germination, less radicle growth, and more seed coat mold growth at seven days. Although several mechanisms are available for removing light weight and immature cottonseed, growers and commercial cottonseed producers should consider the potential effects of whiteflies on seed quality before saving seed produced under heavy infestations.