Information is limited on the tradeoffs of applying a harvest-aid followed by a once-over or twice-over harvest for picker cotton. Factors that influence this decision are: responses of first-harvest yield and quality to the harvest-aid, variation in base and quality prices, and substitution of harvest-aid for second-harvest costs. Results of the partial budgeting analysis that considers these factors show that the Dropp-Prep combination has the greatest potential to increase first harvest and total harvest net revenue.