The choice of tillage practice in cotton production can affect the overall profitability of the enterprise. A five-year study of three tillage practices commonly used in the Coastal Plain region of Southern Georgia compared input expenditures and net returns for cotton within a multi-crop production system. Changes in relative yields, input quantities, and relative expenditure levels are generated for each tillage practice and compared on a current price basis. The study period spans the treatment years of the Georgia Boll Weevil Eradication Program. Comparisons drawn among the study years can suggest the adjustment path for cotton production inputs and outputs under an eradication program. Some insights may also be provided on the expected revenue and expenditure effects from initiating an eradication program in other states when producers employ different tillage practices.