Field trials were conducted during 2008 and 2009 to evaluate glufosinate-resistant (GLFR) cotton response to glufosinate alone or mixed with the plant growth regulator mepiquat chloride with or without 10 insecticides applied to cotton at pinhead square or first bloom. Less than 2% visual injury was observed with any treatment. At both 14 and 28 d after treatment (DAT), mepiquat chloride mixed with glufosinate reduced cotton height 7 to 8 cm and 2 cm when applied at pinhead square and first flower growth stages, respectively, compared to glufosinate applied alone. Insecticides added to glufosinate alone, or glufosinate plus mepiquat chloride had no impact on plant height. Differences in seed cotton yield were not observed, indicating that minimal cotton injury and early season height differences did not influence cotton yield. Glufosinate combined with insecticides and mepiquat chloride, in accordance with herbicide labeling for glufosinate-resistant cotton, offers producers the ability to integrate pest and crop management strategies with crop safety while reducing production costs.