The Southern Extension and Research Information Exchange Group on Soil Testing and Plant Analysis (SERA-6) has proposed a research-based, cooperative, web-based publication to summarize existing research related to soil test calibration and recommendations for cotton on Coastal Plain soils. Since public soil testing laboratories in states with Coastal Plain soils use similar soil test methodology (Mehlich-1 or Mehlich-3 extractants), research should be applicable across state lines. In support of this, long-term soil fertility research at 5 Alabama locations has already been summarized. Interestingly, calibration (critical soil test values for P and K) and interpretations (recommendations) are very similar among those states in this region (AL, FL, GA, NC, SC, and VA). These have been verified by on-going soil fertility experiments in the Coastal Plain of Alabama. Nitrogen rate recommendations and P and K calibrations appear reliable for modern cultivars and cropping systems.