Weed control systems for Roundup Ready cotton were evaluated in a large field trial at the Milan Experiment Station, Milan, Tennessee in 1996. Roundup Ready, Paymaster 1220 cotton was planted in early May, no-till in previous years' cotton stubble. Weeds included cocklebur (Xanthium strumarium), morning-glory (Ipomoea spp.), sicklepod (Senna obtusifolia), yellow nutsedge (Cyperus esculentus) and johnsongrass (Sorghum halepense) as well as crabgrass (Digitaria sanguinalis). Systems varied from traditional pre-emergence soil based residual herbicide programs to total postemergence programs using Roundup Ultra (glyphosate) only as well as mixtures there of. Treatments were applied to eight row wide strips the length of the field with commercial field applications equipment and replicated across the 40 acre field three times. All treatments were conducted in a strictly no-till situation.