Several trials were initiated to evaluate the potential for liquid disulfoton at rates lower than 0.75 lb ai/ac applied in-furrow as a safener for Command 3 ME in cotton. Liquid disulfoton rates evaluated were 0, 0.3, 0.4, 0.5, and 0.75 lb ai/ac, all applied in-furrow at planting. Command 3 ME plus fluometuron at 0.5 + 0.5, 0.75 + 0.75, and 1.0 + 1.0 lb ai/ac, respectively, were applied preemergence after planting. Treatments receiving Command + fluometuron at 0.5 + 0.5 lb ai/ac, resulted in cotton chlorosis of only 4 % at 2 to 3 WAE when disulfoton was applied in-furrow, regardless of disulfoton rate. When command at 0.75 lb ai/ac + fluometuron at 0.75 lb ai/ac was applied PRE, disulfoton at 0.4 lb ai/ac or higher provided effective safening. Foliar chlorosis was negligible by 4 to 5 weeds after emergence at disulfoton rates of 0.4 to 0.75 lb ai/ac and with the highest herbicide rates tested in these trials. At higher Command + fluometuron rates, disulfoton at 0.5 lb ai/ac was most consistent in maintaining stunting and stand reductions at negligible levels (<5%) at 2 to 3 weeks after emergence.