Higher levels of resistance to insects, plant pathogens, and abiotic stresses are needed in cotton cultivars to enhance plant health and increase yield. The multi-adversity resistance (MAR) program has been successful in transferring and developing cotton germplasm with morphological mutant traits known to impart host resistance to pests. The performances of two okra-leaf strains, OSIKRHQWIH-2-94 and OHGPILBHQH-1-96, and a frego bract strain RCBCLCQPIH-1-95 were similar to the commercial cultivars for yield and fiber quality. Progress in yield was not as great in the nectariless, glandless and red-plant color strains. The MAR strains, especially the okra-leaf and frego bract, have simultaneous genetic gains for many traits, and will provide new sources of host-plant resistance to cotton insects and plant pathogens.