Seedling diseases of cotton vary across the cotton belt depending on weather patterns, field histories, planting dates, and soil type. Pythium spp. and Rhizoctonia solani cause serious problems and impact seedling health, stand establishment, and replanting costs. In-furrow fungicides and seed treatments play a role in improving cotton seedling health and overall plant vigor. The use of products such as Ridomil® PC or Ridomil Gold™ PC, Ridomil tank mixtures with Rovral® or Terraclor®, and Apron® can help establish healthy stands and improve yields. Cotton seedling disease control begins with an overall disease management plan which includes: good seed bed preparation, optimum planting dates, high quality seed, good variety selection, seed treatment, good field drainage, and use of an in-furrow fungicide at planting.