Field studies were established in 1996 to evaluate different weed control systems for Roundup Ready cotton. A study was established near Rohwer to evaluate Roundup Ultra (glyphosate) applied alone postemergence (POST), and when following soil applied Treflan (trifluralin) pre-plant incorporated (PPI) and Cotoran (fluometuron) preemergence (PRE). A standard POST treatment of Staple (pyrithiobac) followed by Cotoran plus MSMA post-directed (PDS) was added for comparison purposes. The other study was established near Little Rock to evaluate Roundup Ultra applied alone POST, and following soil applied Zorial (norflurazon) PPI and PRE plus Cotoran PRE. Roundup Ultra tank-mixed with Staple POST was also evaluated.