Field studies were conducted in 1995 at the Delta Branch Experiment Station at Stoneville, MS to evaluate Roundup and Staple with current PRE treatments for weed control in cotton. PPI/PRE treatments included 0.75 lb ai/A Treflan, 0.75 lb/A Treflan plus 0.8 lb/A Cotoran, and 1.0 lb/A Zorial. POST treatments evaluated were 1.0 oz/A Staple (3" cotton) followed by 1.0 oz/A Staple (6" cotton); 0.75 lb ae/A Roundup (3"); and 0.75 lb/A Roundup (3") followed by 0.56 lb/A Roundup (6"). Cotton was planted and PRE applications were made on May 11, 1995. Visual ratings of hemp sesbania [Sesbania exaltata (Raf.) Rydb.], common cocklebur (Xanthium strumarium L.), morningglory species (Ipomoea spp.), and common purslane (Portulaca oleracea L.) control and cotton injury were determined at 9 weeks after planting (WAP).