Stink bugs (Nezara viridula, Acrosternum hilare, and Euschistus servus) caused economic damage in untreated transgenic B.t. cotton in South Carolina under most circumstances in 1995. B.t. cotton planted in May in three locations and treated 1 - 4 times during August and September with methyl parathion exhibited yields that were 20 to 40% higher than in untreated B.t. cotton. Yield losses from stink bugs were associated with the abundance of alternate hosts (corn, garden sites, untreated pecans, wild cherry, blackberries, etc.) near the study sites. Our suggestions for managing B.t. cotton to mini-mize losses from stink bugs include: 1. planting early to avoid higher num-bers of stink bugs moving into the crop from alternate hosts; 2. avoiding areas with abundant alternate hosts (wild or cultivated) or where problems with stink bugs have occurred in other crops such as soybean, corn, vegetables, etc.; 3. monitoring the crop for stink bugs as bolls begin to develop; and 4. treating when best available thresholds are reached. Until more effective thresholds are developed, for 1996 we suggest one bug per six feet of row.